3rd MedChem for Global Health

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Synopsis

Tuberculosis, malaria and diseases caused by a diverse range of pathogens, including flaviviruses (eg dengue, West Nile), kinetoplastids (causative agents of Chagas disease, leishmaniasis, etc) and gut pathogens (worms, bacteria, parasites), remain a cause of high mortality across the globe. Fortunately, an ever-improving understanding of the complex life-cycles of these disease-causing pathogens is presenting increasing opportunities for those seeking to tackle these global health problems.

This meeting will focus on medicinal chemistry approaches to developing new medicines for diseases affecting global health. Keynote talks from international experts from industry and academia, alongside perspectives detailing case histories in drug discovery, will highlight the latest developments in the field whilst also showcasing the opportunity for creativity and innovation.

Who should attend?
Bringing together leading exponents for an exciting spread of themed sessions, the meeting will appeal to anyone with an interest in drug discovery and medicinal chemistry. And with great opportunities for collaborative academic-industrial partnerships and open innovation drug discovery programmes, researchers from both sectors will benefit from the networking opportunities that the meeting will also offer.

Call for Abstracts

Abstracts are invited for short oral presentations, and the final closing date for abstract submission is ..... Early submission is encouraged because spaces are limited and speaker slots are being allocated on a case-by-case basis.

Programme (provisional)

Wednesday
14.30	Registration and refreshments
15.30	Opening remarks Caroline Low, Chair of the Organising Committee and independent consultant
15.35	Welcome Head of Site, GlaxoSmithKline, ES
	Session chair:
15.45	Keynote: Driving drug discovery for global health Peter Warner, Bill and Melinda Gates Foundation, US
16.30	Keynote: Snakebite: the case for action and the need for innovation in treatment approaches Nick Cammack, Wellcome, UK
17.15	Refreshments and exhibition
17.45	Plasmodium autophagy evasion in the liver-stage: mechanisms and novel therapeutic opportunities María Mota, University of Lisbon, PT
18.15	Presentation title to be confirmed Jake Baum, Imperial College London, UK
18.45	Close
Thursday
09.00	Session chair:
09.05	Antimalarial MMV693183 forms a pantothenamide metabolite that blocks acetyl-coenzyme A synthetase in Plasmodium parasites Koen Dechering, TropIQ Health Sciences, NL
09.35	Identification of novel antimalarial chemopreventive therapies María de Gracia Gomez, GlaxoSmithKline, ES
10.05	Refreshments and exhibition
10.35	NTM drug discovery at CDI Thomas Dick, Hackensack Meridian Health, US
11.05	Antibiotic destruction by its target and the limits of irreversible inhibition Luiz Carvalho, Francis Crick Institute, UK
11.35	Short talks (4 x 10 minutes)
12.15	Lunch and exhibition
	Session chair:
13.45	Novel oxazolidinone-class protein synthesis inhibitors with improved safety profiles Brendan M Crowley, MSD, US
14.30	KRS – a novel target for TB, exploited using structure-based drug design Laura Cleghorn, Drug Discovery Unit, University of Dundee, UK
15.00	What makes a good hit and how to get there – lessons learned from NTD hit generation beyond screening Peter Sjö, DNDi (Drugs for Neglected Diseases Initiative), CH
15.30	Refreshments and exhibition
16.00	Presentation title to be confirmed Speaker to be confirmed
16.30	Neglected tropical disease drug discovery through a combination of lead repurposing and distributed drug discovery Michael Pollastri, Northeastern University, US
17.00	The energy metabolism of Leishmania as a drug target Luis Rivas, CIB-CSIC (Biological Research Center of the Spanish National Research Council), ES
17.30	Short talks (3 x 10 minutes)
18.00	Close
19.30	Paella and cocktails on site courtesy of GlaxoSmithKline, Tres Cantos, ES
Friday
09.00	Session chair:
09.05	Results of the proof-of-concept study for the M72/AS01E tuberculosis vaccine candidate Lode Schuerman, GlaxoSmithKline Vaccines, BE
09.50	Microdosing study with malaria clinical candidate APA synthesis Farouk Chughlay, Medicines for Malaria Venture, CH
10.20	Refreshments and exhibition
10.50	A proteasome inhibitors story: from bench to bedside and back again Florencia Segal, Novartis, US
11.20	Presentation title to be confirmed Tim Miles, GlaxoSmithKline, UK
11.50	Short talks (4 x 10 minutes)
12.30	Lunch and exhibition
	Session chair:
14.00	Presentation title to be confirmed Lisa Meier, University of Tübingen, DE
14.30	Bacterial foraging of mucosal sialic acid in intestinal inflammation Thierry Hennet, University of Zurich, CH
15.00	Pharmacological interventions for the treatment of enteric bacteria Elena Fernández Alvaro, GlaxoSmithKline, ES
15.30	Closing remarks Speaker name, affiliation
15.45	Close

Confirmed Short Talks (10 minutes each)

Combination therapy for a new treatment for Chagas disease?
Carlos Montanari, University of São Paulo, Brazil

Synthesis and evaluation of cyclopeptides containing N-methyl amino acids as promising antiplasmodial agents
Gloria Serra, Universidad de la República, Uruguay

Registration, Fees and Bursaries

This event has been postponed and may be held as a physical event in 2022

* Student is undergraduate or post-graduate, not post-doc, and does not apply to students in paid employment.
Member is paid-up member of the RSC, SCI or SEQT.

Students may apply for a bursary to support registration, travel and accommodation costs, and the closing date for applications is .....

Student members of the SEQT will receive a direct invitation from the SEQT to apply for a bursary to attend this event.

Cancellation Policy

In the event of cancellation by ...., 80% of the fee paid will be refunded. Cancellations must be received in writing. Refunds will not be possible after that date although substitutions are possible at any time. In the unlikely event of cancellation of the meeting, fees paid will be refunded in full.

Exhibition

The exhibition will be situated in a single area just outside of the lecture theatre, ensuring excellent access to delegates throughout the meeting.

The exhibition charge of £.... includes:

- one full delegate's attendance

- logo in rolling slides and delegate handbook

- single promotional page in printed delegate handbook

Delegate pack inserts may be booked at £200 - no more than two sheets of A4 fixed together.

Sponsorship

Sponsors are encouraged to support this established event. Sponsorship will support the low registration fees being offered to students.

This event is organised jointly by the:

- Royal Society of Chemistry’s Biological and Medicinal Chemistry Sector (RSC BMCS)
- Society of Chemical Industry’s Fine Chemicals Group (SCI FCG)
- Sociedad Española de Química Terapéutica (SEQT)

We are grateful to EFMC for supporting this event

Venue and Travel

Address: Trelegy Auditorium, GlaxoSmithKline, Technology Park of Madrid, C / Severo Ochoa 2, 28760 - Tres Cantos, Madrid, Spain

Air: Madrid airport (Adolfo Suárez Madrid-Barajas) has a railway station at Terminal 4. A free shuttle bus runs from outside Terminals 1, 2 and 3 to Terminal 4.

Rail: Airport to Tres Cantos with one change at Chamartin station: less than 1 hour. Airport to Madrid Atocha central railway station: 25 minutes. Service provider is Renfe Cercanías. Download a plan of the railway routes here.

Taxi: Airport to Tres Cantos costs about €50: 30 minutes.

Car: A limited number of car parking spaces is available on site at GSK and these will be allocated on a "first come, first served" basis. Please book your car parking as part of the registration process and provide your vehicle's registration number.

Accommodation

We plan to hold a limited number of rooms with two hotels in Tres Cantos at preferential rates as below.

Hotel	Eurostars Madrid Foro
Address	Ronda de Europa ,1 Madrid - Tres Cantos 28760
Telephone	+34 918 054720
Contact	Lara Recio
Rates	For the first ten rooms: €97.90 B&B (2021 rate, to be updated) For the remaining rooms: €119 B&B (2021 rate, to be updated)
Basis	Bedroom on bed and breakfast basis
To book	Contact Lara Recio direct by e-mail, using the booking code “MCGH June 2020”.
Release	Any bedrooms not booked will be released on 21st May

Hotel	Exe Tres Cantos
Address	Plaza de la Estación 2 Madrid, Tres Cantos 28760
Telephone	+34 918 044837
Contact	Loreto Vicente
Rates	€128 (Tue and Wed), €113 (Thu) (2021 rates, to be updated)
Basis	Bedroom on bed and breakfast basis
To book	Contact Loreto Vicente direct by e-mail, using the booking code “MCGH June 2020”. The hotel will collect your card details in order to hold your reservation.
Release	Any bedrooms not booked will be released on 21st May

Organising Committee

Carlos Alemparte	GlaxoSmithKline
Dave Alker (treasurer)	Independent Consultant
Félix Calderón	GlaxoSmithKline
Liam Cox	University of Birmingham
José Fiandor	GlaxoSmithKline
Caroline Low (chair)	Independent Consultant
Maria Marco-Martin	GlaxoSmithKline
Ana Rosa Merino-Nieto	GlaxoSmithKline
Cristina Ramos	GlaxoSmithKline
Andrew Stachulski	University of Liverpool

Secretariat Contact

to be confirmed

This event has been postponed

and may be held as a physical event in 2022