BMCS 2nd Conformational Design in Drug Discovery 2025
Event
BMCS 2nd Conformational Design in Drug Discovery
Dates
Monday 3rd March 2025
Place
AstraZeneca, Cambridge, UK
The Discovery Centre
Cambridge Biomedical Campus
1 Francis Crick Avenue
Cambridge
CB2 0AA
Synopsis
Conformational Design plays a key role in the medicinal chemistry of small molecule drug candidates. The emergence of generative AI models to assist molecular design and free-energy-perturbation techniques critically depend on accurate prediction of 3D ligand conformations. Here we bring together cutting-edge computational methods with experimental free ligand NMR solution conformations and protein-ligand X-ray and CryoEM structures to craft the medicines of tomorrow. We will discuss ligand rigidification and physicochemical optimisation strategies for protein-protein interaction inhibitors, PROTACs, molecular glues, antibody-drug-conjugate payloads and other new modalities. This RSC-BMCS event aims at building a community that shares conformational design strategies, technologies, and successful case studies. It will complement other rational drug design events and promote more successful research into future medicines.
Who should attend?
This symposium will provide great learnings for medicinal chemists, computational chemists, structural biologists, biophysicists and NMR analytical chemists with an academic or industry interest in drug discovery. Prior knowledge in conformational design will not be required.
Want to become a member?
To join the RSC in order to qualify for discounted registration fees at all RSC events, please follow this RSC link.
Registration
Please click here to register.
Registration Fees:
RSC Member – £115.00
Non-Member – £165.00
RSC Student Member – £40.00
Student Non-Member – £60.00
Call for Abstracts
Abstract submissions are open for oral and poster presenations. Please click here to submit an abstract. The deadline for abstract submission is Midnight (GMT) Friday 6 December 2024.
Important links and downloads
X (formerly twitter) hashtag – #ConformationalDesign25
Please click here for information on how to get to the venue
Please click here to register
Please click here to submit an abstract.
Sponsorship/Exhibition Opportunities
Bookings to sponsor or exhibit at the meeting are now open, click here to register.
Exhibition Package includes (£900):
– Two stand personnel with access to the scientific talks
– A table and 2 chairs
– Your logo and A4 promotional page in the pdf of the delegate handbook
– Your logo in the rolling slides, shown during the breaks
Confirmed Exhibitors
Confirmed Speakers
Jovan Damjanovic, Novo Nordisk
Synergistic AI/physics approach to structure-based design of druglike peptidic macrocycles
Ruth Dooley, Evotec
Harnessing Conformational Drivers in Drug Discovery
Thomas Fuchss, Merck Group
ATM kinase inhibitor lartesertib
Ed Harder, Schrodinger
OPLS5 – Molecular Mechanics Force Field and Its Applications
Bernd Kuhn, Roche
Leveraging Conformational Insights for Efficient Inhibitor Design Against Neurological Targets
Hendrik Moebitz, Novartis
Design Principles for Balancing Lipophilicity and Permeability in beyond Rule of 5 Space
Henriette Williams, University of Cambridge
TBC
Fabio Montisci, Cambridge Crystallographic Data Centre
Data-driven PROTAC conformer ensemble generation and docking
Gustavo Bezerra, BicycleTx
Identification of potent angiotensin-converting enzyme 2 (ACE2) binders using a unique phage display platform: conformational insights and therapeutic potential
Organising Committee
Markus Schade, AstraZeneca (Chair)
Chris Swain, Cambridge MedChem Consulting (Treasurer)
Luca Carlino, AstraZenceca
Secretariat Contact and Further Information
Hg3 Conferences Ltd
+44 (0)1423 529333
events@hg3.co.uk
