BMCS 2nd Conformational Design in Drug Discovery 2025
Event
BMCS 2nd Conformational Design in Drug Discovery
Dates
Monday 3rd March 2025
Place
AstraZeneca, Cambridge, UK
The Discovery Centre
Cambridge Biomedical Campus
1 Francis Crick Avenue
Cambridge
CB2 0AA
Synopsis
Conformational Design plays a key role in the medicinal chemistry of small molecule drug candidates. The emergence of generative AI models to assist molecular design and free-energy-perturbation techniques critically depend on accurate prediction of 3D ligand conformations. Here we bring together cutting-edge computational methods with experimental free ligand NMR solution conformations and protein-ligand X-ray and CryoEM structures to craft the medicines of tomorrow. We will discuss ligand rigidification and physicochemical optimisation strategies for protein-protein interaction inhibitors, PROTACs, molecular glues, antibody-drug-conjugate payloads and other new modalities. This RSC-BMCS event aims at building a community that shares conformational design strategies, technologies, and successful case studies. It will complement other rational drug design events and promote more successful research into future medicines.
Who should attend?
This symposium will provide great learnings for medicinal chemists, computational chemists, structural biologists, biophysicists and NMR analytical chemists with an academic or industry interest in drug discovery. Prior knowledge in conformational design will not be required.
Want to become a member?
To join the RSC in order to qualify for discounted registration fees at all RSC events, please follow this RSC link.
Registration
Registration will be open shortly. Please keep checking the website for updates.
Call for Abstracts
Abstract submissions will be open shortly. Please keep checking the website for updates.
Important links and downloads
X (formerly twitter) hashtag – #ConformationalDesign25
Organising Committee
Markus Schade, AstraZeneca (Chair)
Chris Swain, Cambridge MedChem Consulting (Treasurer)
Sharan Bagal, AstraZeneca
Luca Carlino, AstraZenceca
Tim Barrett, GSK
Secretariat Contact and Further Information
Hg3 Conferences Ltd
+44 (0)1423 529333
events@hg3.co.uk