RSC-BMCS 4th Conformational Design in Drug Discovery 2027
Event
RSC-BMCS 4th Conformational Design in Drug Discovery
Dates
Monday 1st March, 2027
Place
Burlington House, London
Downloads and Links
Social media hashtag – #ConformationalDesign27
Synopsis
Conformational Design plays a key role in the medicinal chemistry of small molecule drug candidates. The emergence of generative AI models to assist molecular design and free-energy-perturbation techniques critically depend on accurate prediction of 3D ligand conformations. Here we bring together cutting-edge computational methods with experimental free ligand NMR solution conformations and protein-ligand X-ray and CryoEM structures to craft the medicines of tomorrow. We will discuss ligand rigidification and physicochemical optimisation strategies for protein-protein interaction inhibitors, PROTACs, molecular glues, antibody-drug-conjugate payloads and other new modalities. This RSC-BMCS event aims at building a community that shares conformational design strategies, technologies, and successful case studies. It will complement other rational drug design events and promote more successful research into future medicines.
Who should attend?
This symposium will provide great learnings for medicinal chemists, computational chemists, structural biologists, biophysicists and NMR analytical chemists with an academic or industry interest in drug discovery. Prior knowledge in conformational design will not be required.
Want to become a member?
To join the RSC in order to qualify for discounted registration fees at all RSC events, please follow this RSC link.
Bursaries
Bursary information will be available shortly.
Registration
Registration will open shortly.
Abstracts
Abstract submission will open shortly.
Sponsorship/Exhibition Opportunities
Bookings to exhibit or sponsor this meeting will open shortly.
Organising Committee
Markus Schade, AstraZeneca (Chair)
Martin Swarbrick, Pharmaron (Treasurer)
Luca Carlino, AstraZeneca
Tim Barrett, GSK
A. Ganesan, Liverpool John Moore’s University
Hannah Bruce Macdonald, Isomorphic Labs
Secretariat Contact and Further Information
Hg3 Conferences Ltd
+44 (0)1423 529333
E-mail