Events

5th RSC / DMDG / DMG New Perspectives in DMPK

Event
5th RSC / DMDG / DMG New Perspectives in DMPK

Dates
Tuesday-Wednesday, 22nd-23rd February 2022

Place
Liverpool Medical Institution & Conference Centre, Liverpool, UK

Downloads and Links
First announcement
Abstract template – closing dates are 25th November (oral) and 13th January (poster)
DMPK – bursary application form – closing date is 7th January
Twitter hashtag – #DMPK22

Synopsis
Members from across the DMPK research community are encouraged to join colleagues from across academic, industrial, and third-sector institutions and contribute to the ongoing discussion, evolution and application of DMPK in various scenarios.

The event programme will incorporate sessions themed around the following key topics:
– DMPK and Drug Discovery
– DMPK and Drug Safety
– Analytical and Computational Advances in DMPK

In addition, the programme also includes a keynote talk, ‘flash’ presentations from early career researchers, and opportunities for open debate and discussion.

Programme Themes
Session 1 – DMPK and Drug Discovery
Understanding chemical and biological interactions that mediate pharmacological and toxicological effects of drugs and their metabolites is an important part of the drug discovery picture. In this session, we will showcase some of the more recent developments in our collective understanding.

Session 2 – DMPK and Drug Safety
This session will provide an interdisciplinary platform for academics and scientists to present and discuss the most recent innovations and practical challenges in the fields of DMPK to address drug safety, and particularly the emerging safety issues relating to biotherapeutics. It will include presentations on transporters associated with drug-induced tissue injury, new in vitro models for mechanistic toxicity assessment, and recent developments in predicting intrinsic immunogenicity of drugs.

Session 3 – Analytical and Computational Advances in DMPK
Advances in analytical and computational performance, and the availability of new instruments, methods, and approaches commonly unlocks new knowledge about compound stability, reactivity, interaction, and disposition. This session will showcase recent developments in bioanalytical science and computational modelling that have provided fresh insight and understanding in DMPK.

Who should attend
Medicinal chemists, drug discovery scientists, pharmacologists, toxicologists, DMPK scientists – from academia, industry, and third sector institutions.

Call for Abstracts
The call for both oral and poster abstracts is open, and the closing dates are 25th November (oral) and 13th January (poster). At the time of submission, poster presenters are asked whether they wish also to be considered for a short oral presentation.

To submit an abstract, please download and submit this template.

Programme

Tuesday, 22nd February

12.00Registration and lunch
13.00Welcome
Toby Athersuch, Imperial College London, UK
Joint Organising Committee (RSC-BMCS, DMDG, DMG)
Liverpool Local Organising Committee
13.10Keynote presentation: Metabolism of strained rings: tales of the unexpected
Martin Hayes, AstraZeneca, SE
Flash poster presentations
14.00Blood-brain barrier “on-a-chip” model for testing drug permeability into the brain (poster)
Chloë Whitehouse, University of Nottingham, UK
14.05Presentation title to be confirmed (poster)
Presenter to be confirmed
14.10Presentation title to be confirmed (poster)
Presenter to be confirmed
DMPK and Drug Discovery I – Chemistry and Mechanisms
14.15“The secret life of acyl glucuronides”
Andrew Stachulski, University of Liverpool, UK
14.55Presentation title to be confirmed
Presenter to be confirmed
15.35Refreshments, exhibition and posters
DMPK and Drug Discovery II – Application and Strategy
16.15Is drug lipidation a new paradigm in DMPK?
John Sanderson, Durham University, UK
16.55Presentation title to be confirmed
Presenter to be confirmed
17.35Close
18.00Drinks reception
19.00Conference dinner (optional)
22.30Close

Wednesday, 23rd February

 Drug Discovery and Drug Safety I – Small Molecules
09.00Acyl glucuronides in perspective
Ian Wilson, Imperial College London, UK
09.40"The ADME and PKPD profile of an Ion Channel Blocker for a Hot Target"
Dr Kevin Beaumont, AstraZeneca, Cambridge, UK
10.20Refreshments, exhibition and posters
Drug Discovery and Drug Safety II - Biologics
10.40Presentation title to be confirmed
Speaker to be confirmed
11.20Optimising proteolysis targeting chimeras (PROTACs) for oral drug delivery: A drug metabolism and pharmacokinetics perspective
Andy Pike, AstraZeneca Ltd, UK
12.00Presentation title to be confirmed
Speaker to be confirmed
12.40Lunch, exhibition and posters
Analytical and Computational Advances in DMPK
14.00Prediction of DILI using 3D liver microtissues
Lynsey Chatham, Cyprotex Discovery Ltd, UK
14.40One-stop metabolite shop: employing multiple tools for accessing drug metabolites
Julia Shanu-Wilson, Hypha Discovery Ltd, UK
15.20Finding the metabolite needle in a matrix haystack
James O’Neill, Charles River Laboratories, UK
16.00Closing remarks

 

Want to become a member?
To join the RSC in order to qualify for discounted registration fees at all RSC, please follow this RSC link.

Student Bursaries
The RSC BMCS and DMDG are offering some student bursaries to cover the registration fee, and eligible travel and accommodation expenses.  Applications are invited from PhD and post-doctoral students studying at an academic institution, preferably members of the RSC, DMDG or EFMC.

The closing date for bursary application is 7th January, and you may download this bursary application form.

 

We are grateful to our supporter: EFMC

Organising Committee
Toby Athersuch (chairman), Imperial College London and the DMG
Xiaoli Meng, University of Liverpool
Dean Naisbitt, University of Liverpool
Mark Seymour, PharMAS Consulting and DMDG
Andrew Stachulski (treasurer), University of Liverpool and RSC-BMCS

Secretariat Contact and Further Information
Stuart Hex, DMDG, UK
+44 (0)116 274 7352
E-mail