3rd RSC / SCI New Therapeutics for Global Health
Event
3rd RSC / SCI New Therapeutics for Global Health
Dates
Monday 9th – Wednesday 11th September, 2024
Place
Cranfield Management Development Centre, Cranfield University, Milton Keynes, UK
Important links and downloads
Twitter hashtag – #NTGH24
To download the venue guide, click here
To download the third announcement poster, click here
To submit an abstract, click here
To register for the event, click here
To apply for a bursary, click here
Synopsis
Tuberculosis, malaria and diseases caused by a diverse range of pathogens, including flaviviruses (eg dengue, West Nile), kinetoplastids (causative agents of Chagas disease, leishmaniasis, etc) and gut pathogens (worms, bacteria, parasites), remain a cause of high mortality across the globe. Fortunately, an ever-improving understanding of the complex life-cycles of these disease-causing pathogens is presenting increasing opportunities for those seeking to tackle these global health problems.
This meeting will focus on medicinal chemistry approaches to developing new medicines for diseases affecting global health. Keynote talks from international experts from industry and academia, alongside perspectives detailing case histories in drug discovery, will highlight the latest developments in the field whilst also showcasing the opportunity for creativity and innovation
Call for abstracts:
Abstract submission is now closed.
The oral submission deadline has now passed.
Bursaries
Bursaries are available from both the RSC and SCI. Applications are welcomed from any PhD or post-doctoral student studying at an academic institution irrespective of their nationality. The applicant is preferably an RSC or SCI member or member of a *National Adhering Organisation of the EFMC and is encouraged to present a short talk at the event (applications from those submitting short talk abstracts will be favoured). Applications must be endorsed by the student’s supervisor. Bursary applications are also invited from RSC, SCI or EFMC members who are of working age, but currently unemployed. We also welcome bursary applications from those who may have difficulty funding themselves or whose organisations may have difficulty funding their attendance.
The Bursary submission deadline was Friday 9th August.
Registration
Registration is now open! Please click here to register. The final deadline for registrations is 17:00 (BST) Monday 2nd September 2024.
Registration fees:
| Registration Rate | |
| RSC/SCI Member* | £320.00 |
| Non-member Standard | £400.00 |
| RSC/SCI Student** member* | £175.00 |
| Student** non-member | £250.00 |
| Member* LMIC*** | Contact Hg3 |
| Non-member LMIC*** | Contact Hg3 |
| Student** member* LMIC*** | Contact Hg3 |
| Student** non-member LMIC*** | Contact Hg3 |
.
Provisional Programme
| Monday 9th September | |
| 12.00 onwards | Registration Arrival Refreshments – Mitchell Building |
| 14.00 – 14.10 | Opening remarks Mary Wheldon – Organising Committee |
| Chair: Andrew Stachulski | |
| 14.10 – 14.55 | “Progress and challenges in treating global health diseases”
Plenary – Peter Warner (Gates Foundation) |
| 14.55 – 15.40
|
“Development of anti-malarial drug discovery in Ghana”
Richard K Amewu (University of Ghana) |
| 15.40 – 16.00 | *Short Talk* “Accelerating Discovery: Leveraging CDD Vault for Innovations in Global Health Pathogen Research”
Susana Tomásio (CDD) |
| 16.00 | Flash presentations (2 mins no Q & A)
FO1: Probing a novel allosteric binding site in Mycobacterium tuberculosis DNA gyrase to tackle Tuberculosis and antimicrobial resistance
FO2: Synthesis and Antischistosomal Structure-Activity Relationship Profiling of N-Pyridazin-3-ylbenzamides FO3: Open MMV Global Health Priority Box: a strategy for identifying dengue protease inhibitors and developing new drug discovery projects in Argentina FO4: Pyrazolopyridine derivatives as potent inhibitors of Trypanosoma brucei GSK-3β for the treatment of human African trypanosomiasis FO5: CDD African Program: Modernizing Labs and Empowering Research Teams with CDD Vault
FO6: Medicinal Chemistry Optimisation of Novel Heterocyclic Anti-infective Agents |
| 16.30 onwards | Drinks reception, poster session and exhibition viewing time |
| 19.00 | Buffet dinner – CMDC Restaurant |
| Tuesday 10th September | |
| 8.30 | Registration – Mitchell Building |
| Malaria Session – Chair: Martin Lowe | |
| 09.20 | Welcome by chair |
| 09.30 – 10.15
|
“Identifying new therapeutic options to overcome
malaria resistance” Laura M Sanz-Alonso (GSK) |
| 10.15 – 11.00 | “Design of Potent and Orally Available Antimalarial PMX Inhibitors via Molecular Property Optimization”
Teresa de Haro (UCB) |
| 11.00-11.30 | Coffee / Exhibition and Poster Viewing |
| 11.30 – 11.50 | *Short Talk* “Selective covalent inhibition of the essential malarial protein kinase PfCLK3”
Andrew Jamieson (University of Glasgow) |
| 11.50 – 12.35 | “Antimalarial Research & Drug Discovery – tackling the next frontiers”
Jeremy Burrows (MMV) |
| 12.35 – 12.55 | *Short Talk* “Open Source Malaria: Potent Theinopyrimidine-based Sulfonamides with a Novel “Reaction Hijacking” Mechanism Against Plasmodium falciparum Asparagine tRNA Synthetase.”
Yinuo Wang (University College London) |
| 12.55 – 14.00 | Lunch Break, poster session and exhibition Viewing time |
| Antivirals/AMR Session – Chair: Giancarlo Biagini | |
| 14.00 – 14.45 | “Long acting medicines for treatment and prevention of
high burden pathogens in low- and middle-income countries” Andrew Owen (University of Liverpool) |
| 14.45 – 15.30 | “New Antivirals: AI and Structure Based Open Science and direct-to-generic approaches”
Ed Griffin (MedChemica Ltd) |
| 15.30-16.00 | Coffee / Exhibition and Poster Viewing |
| 16.00 – 16.20 | *Short Talk* “Accessing new antibacterial targets and modalities through integrated chemistry and genetics”
Eachan Johnson (The Francis Crick Institute) |
| 16.20-16.40 | *Short Talk* “Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors”
Michael Thomas (University of Dundee) |
| 16.40 – 17.30 | Panel Discussion |
| 17.30 – 18.00 | Poster Session |
| 19.00 | Conference Dinner – CMDC Restaurant |
| Wednesday 11th September | |
| 8.30-17.00 | Registration – Mitchell Building |
| NTD Session – Chair: Jayshree Mistry | |
| 9.20 | Welcome by chair |
| 09.30 – 10.15 | “New treatments for cryptosporidiosis with optimal properties for targeting gastrointestinal infection”
Nicola Caldwell (University of Dundee) |
| 10.15 – 11.00 | “The discovery of a novel series of compounds with single-dose efficacy against juvenile and adult Schistosoma species”
Mark Gardner (Salvensis) |
| 11.00 – 11.30 | Coffee / Exhibition Poster Viewing |
| 11.30 – 11.50 | *Short Talk* “Covalent Tools For Essential Leishmania Bromodomain LdBDF5”
Claudine Greenwood (GSK) |
| 11:50 – 12.35 | “End-to-end drug discovery in endemic areas: a Chagas disease case study” Luiza Cruz (DNDi) |
| 12.35 – 13.45 | Lunch Break, poster session and exhibition viewing time |
| TB Session – Chair: Mary Wheldon | |
| 13.45 – 14.30 | “Discovering new TB agents for the future with novel modes of action”
Laura Cleghorn (University of Dundee)
|
| 14.30 – 15.15 | “Next Generation Oxazolidinone Antibiotics for the Treatment of Tuberculosis”
Brendan Cowley (Merck) |
| 15.15-16.00 | “TB Drug Discovery at H3D: Biology and Chemistry Working Together to Deliver a Preclinical Candidate”
Sandeep Ghorpade |
| 16.00 | Meeting closing remarks and poster prize giving |
| 16.15 | Conference Closes |
Venue and Travel
Detailed travel information can be found in this Venue Guide or the venue website here.
Want to become a member?
To join the RSC in order to qualify for discounted registration fees at all RSC, please follow this RSC link.
Exhibition/Sponsorship Opportunities
The Exhibitor Package (£1,500) comprises:
- A six foot trestle table and chairs
- Access to electricity and wi-fi
- Logo inclusion in pdf of delegate handbook and rolling slides and conference website
- Exhibitors promotional page in the pdf delegate handbook
- One stand personnel with access to technical sessions
The Sponsorship Package (from £500) comprises:
- your logo in the delegate handbook
- your web-linked company name on the event web page
- your logo in the rolling slides, shown during the breaks and verbal thanks from meeting chair
Confirmed Speakers
Development of anti-malarial drug discovery in Ghana
Richard K Amewu, University of Ghana
Antimalarial Research & Drug Discovery – tackling the next frontiers
Jeremy Burrows, Medicines for Malaria Venture
New treatments for cryptosporidiosis with optimal properties for targeting gastrointestinal infection
Nicola Caldwell, University of Dundee
Discovering new TB agents for the future with novel modes of action
Laura Cleghorn, University of Dundee
Next Generation Oxazolidinone Antibiotics for the Treatment of Tuberculosis
Brendan Cowley, Merck (MSD)
End-to-end drug discovery in endemic areas: a Chagas disease case study
Luiza Cruz, DNDi
Design of Potent and Orally Available Antimalarial PMX Inhibitors via Molecular Property Optimization
Teresa De Haro, UCB Biopharma
The discovery of a novel series of compounds with single-dose efficacy against juvenile and adult Schistosoma species
Mark Gardner, Salvensis
TB Drug Discovery at H3D: Biology and Chemistry Working Together to Deliver a Preclinical Candidate
Sandeep Ghorpade, University of Capetown
New Antivirals: AI and Structure Based Open Science and direct-to-generic approaches
Ed Griffen, MedChemica Ltd
Long acting medicines for treatment and prevention of high burden pathogens in low- and middle-income countries
Andrew Owen, University of Liverpool
Identifying new therapeutic options to overcome malaria resistance
Laura M Sanz-Alonso, GSK
Progress and challenges in treating global health diseases
Peter Warner, Bill & Melinda Gates Foundation
Sponsors
We are grateful to our confirmed sponsors for their valued support
Exhibitors
Organising Committee
Giancarlo Biagini – Liverpool School of Tropical Medicine
Martin Lowe (SCI) Chair
Jayshree Mistry (SCI) – Independent Consultant
Andrew Stachulski – BMCS University of Liverpool
Mary Wheldon (BMCS) Treasurer
Secretariat Contact and Further Information
Hg3 Conferences Ltd
+44 (0)1423 529333
E-mail
