7th RSC-BMCS / SCI Symposium on Ion Channels as Therapeutic Targets

7th RSC-BMCS / SCI symposium on Ion Channels as Therapeutic Targets

Monday – Tuesday, 27th-28th March 2023

Hinxton Hall, Wellcome Genome Campus, Cambridge

Important links and downloads
Handbook – click here
Twitter hashtag – #IonChannels23

First Announcement Poster available to view here
Second Announcement Poster available to view here

Ion channels are important targets for therapeutic intervention due to their extensive roles in human physiology and the pathophysiology of disease. Many successful drugs targeting this gene family have been discovered for diseases such as hypertension, epilepsy and neuropathic pain.  This symposium, the 7th in an ongoing series, will showcase the most recent advances to aid the design of new ion channel therapeutics and promote interaction between scientists with a shared interest in the field of ion channel drug discovery.

Who should attend
Scientists from industry and academia interested in the therapeutic potential of ion channels. The organising committee particularly welcomes attendance and participation of students or early career researchers working in the field of ion channels.

Call for Abstracts
The oral and poster deadline has now passed.

Registration is now closed. The Early-bird deadline is Monday 30th January 2023.

Registration fees will include the conference dinner. Limited on-site accommodation is available to book by following the instructions in your registration confirmationemail you will receive shortly after registering.

Student Bursaries
The RSC BMCS are offering some student bursaries to attend this meeting in person. Applications are now closed.


Monday 27th March

09:30 - 10:30Registration & Refreshments
10:30 - 12:20Session 1: Chair - Professor Brian Cox, University of Sussex
10:30Opening Remarks - Professor Brian Cox, University of Sussex
10:40 - 11:15Professor Stephen Tucker, University of Oxford
Defective gating underlies a novel K2P channelopathy associated with sleep apnea
11:15 - 11:50Dr Michael Hahn, Bayer AG Pharmaceuticals
Discovery of the TASK-1 and TASK-3 Channel Blocker BAY 2586116 for the Treatment of Obstructive Sleep Apnea (OSA)
11:50 - 12:20Flash Oral Presentations
12:20 - 13:30Lunch, exhibition and poster session
13:30 - 14:45Session 2: Chair - Dr Nigel Swain, Sosei Heptares
13:30 - 13:50Dr Alexandra Pinggera, Metrion Biosciences
Dynamic action potential clamp to investigate ion channel pharmacology
13:50 - 14:10
Dr Damian Bell, Sophion
Functional evaluation of snake neurotoxins and recombinant antibody antivenoms via automated patch clamp 
14:10 - 14:30Dr Anna Rowland, Cerevance
Identification of THIK-1 as a therapeutic target for neuroinflammatory diseases: discovery and characterisation of a selective THIK-1 blocker
14:30 - 14:50Dr Manuela Cerina, Eliem Therapeutics
Discovery and characterisation of ETX-123, a novel Kv7.2/K7.3 activator for the treatment of Epilepsy
14:50 - 15:20Refreshments, exhibition and poster session
15:20 - 17:05Session 3: Chair - Dr Sarah Major, Evotec
15:20 - 15:55Dr Anna Carbone, Evotec
EVOchannel: tune in to safe molecules
15:55 - 16:30Dr Alex Abela, Vertex
Discovery of CFTR modulators for the treatment of Cystic Fibrosis
16:30 - 17:05Dr Jose Maria Cid, Jansen R&D
GluN2B PAMS as enhancers of synaptic plasticity for the treatment of Alzheimer´s disease
17:05 - 19:00Networking reception and posters
19:00 - 21:00Conference Dinner

Tuesday 28th March

9:00 - 10:45Session 4: Chair - Dr Nadia Ahmad, Charles River Laboratories
09:00 - 09:35 Dr Mark Healy, Novartis
The discovery of the NMDA receptor NR2B NAM, MIJ821, a novel, rapidly acting antidepressant
09:35 - 10:10Dr Myriem El Qacemi, Syngenta
The discovery of isocycloseram: a novel isoxazoline insecticide
10:10 - 10:45Dr Giuseppe Cecere, F. Hoffmann-La Roche Ltd
Discovery of First-in-Class Subtype Selective GABAA Alpha5 Positive Allosteric Modulators (PAMs) for the treatment of neurological disorders
10:45 - 11:15Refreshments, exhibition and poster session
11:15 - 13:00Session 5: Chair - Dr Mike Clegg, MSD
11:15 - 11:50Dr Anna Junker, University of Muenster
P2X ion channels as promising therapeutic and diagnostic targets: From the discovery of the first orthosteric P2X7R selective agonist to the development of optical probes for the imaging of P2X7R expression
11:50 - 12:25Dr Simon Holton, Nuvisan
Cryo-EM Structural Studies of The Human TRPV4 Ion-Channel
12:25 - 13:00Dr Luca Raveglia, Evotec
From High-Throughput Screening to Target Validation: Benzo[d]isothiazoles as Potent and Selective Agonists of Human TRPM5 Possessing In Vivo Gastrointestinal Prokinetic Activity in Rodents
13:00 - 14:10Lunch, exhibition and poster session
14:10 - 15:40Session 6: Chair - Sarah Major, Evotec
14:10 - 14:20Poster Prize Presentation
14:10 - 14:55Dr Steve Griffin, University of Leeds
Plugging the holes in antiviral therapy – Drug discovery potential of viroporins to treat SARS-CoV2
14:55 - 15:30Dr Shawn Stachel, MSD
Chemistry accelerated invention of a highly potent oral Nav1.8 channel blocker for the treatment of pain
15:30Closing Remarks - Dr Sarah Major, Evotec
15:40Meeting close

Exhibitor Opportunity – Exhibitor Stands now fully booked!
The exhibitor package comprises-
– Stand space measuring 3 metres wide x 2 metres deep
– Table measuring 240cm wide x 80cm deep and chair
– Electrical and wifi access
– One stand personnel
– Your logo and full promotional page in the delegate handbook
– Your logo in the rolling slide, shown during the breaks
– Full attendance at the technical programme, poster sessions and conference evening dinner for stand personnel 

£950.00 including one full delegate
£1,200 including two full delegates

Sponsor Opportunities
Sponsorship includes –
– Your logo in the pre-event announcements
– Your logo in the delegate handbook
– Your logo in the rolling slides, shown during the breaks

Minimum suggested sponsorship amount is £500.00

Sponsored Lanyards – £250.00
– Delegate lanyards with company logo, sponsor provides


Confirmed Sponsors
We are grateful to our confirmed sponsors for their valued support.


Confirmed Exhibitors
We are grateful to our confirmed exhibitors for their valued support.











Organising Committee
Karl Collins, Bayer Foundation (co-Treasurer)
Brian Cox, University of Sussex
Sarah Major, Evotec (Chair)
Nigel Swain, Sosei Heptares
Rose Bardell-Cox, Evotec (co-Treasurer)
Mike Clegg, MSD
Nadia Ahmad, Charles River Laboratories

Secretariat Contact
Hg3 Conferences Ltd
+44 (0)1423 529333