34th Medicinal Chemistry in Eastern England

34th Medicinal Chemistry in Eastern England

Thursday, 27th April 2023

Fielder Centre, Hatfield

Important links
Twitter hashtag – #HatfieldMedChem23
First Announcement poster
Second Announcement poster

Known colloquially as the “Hatfield MedChem” meeting, this is a highly successful, long-standing, one-day meeting that runs annually. The scientific program will comprise presentations showcasing medicinal chemistry case studies from tools to candidates, across a range of modalities, therapeutic areas and target classes, as well as covering more general topics at the forefront of drug discovery. The meeting aims to be informal and interactive, and is ideal for all those working in medicinal chemistry and drug discovery more widely.


Chair: Simon Ward, Medicines Discovery Institute, Cardiff University, UK
09:30Welcome and Introduction
09:40Identification of H4R Antagonist HTL0032547 as a potential therapy for Atopic Dermatitis
Charlotte Fieldhouse, Heptares, UK
10:20Optimisation of aminofurazans leading to orally bioavailable and CNS penetrant inhibitors of MSK-1 (Mitogen and Stress-Activated Kinase 1)
Anne Valade, UCB, Belgium
11:30Isoform-Selective EPAC Activators: Therapeutic Opportunities for Cardiopulmonary Inflammation
Graeme Barker, Heriot-Watt University, UK
11:55Discovery of novel LpxA inhibitors targeting Pseudomonas aeruginosa
Alastair Parkes, Evotec, UK
12:20Electrostatic Complementarity in Structure-Based Drug Design
James Day, Astex, UK
Chair: Margarita Puente-Felipe,
GSK, Spain
14:15Next Generation Antibody-Drug Conjugates
David Spring, Cambridge University, UK
14:55AI-driven approach to the discovery of novel Mpro inhibitors with high pan-coronavirus activity
Marco Derudas, ExScientia, UK
15:50Combining surface chemistry with affinity selection mass spectrometry accelerates drug discovery for protein and oligonucleotide targets
Zachary Gurard-Levin, SAMDI Tech a Charles River company, US
16:15Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C
Doyle Cassar, AstraZeneca, UK
16:55Concluding Remarks
17:00Meeting Close

Registrations are now closed!

Registration Fees
RSC Member* £135
Non-Member £185
RSC Student ** Member* (Undergraduate and post-graduate)  £65
Student** Non-Member (Undergraduate and post-graduate) £95
Unemployed Member £65
Unemployed Non-Member £95
Retired Member £40

* Member is a paid-up member of the RSC
** Student rates apply to undergraduate and post-graduate students only, but not post-doctoral students.

Sponsorship Opportunities 

Registrations are now closed!

The Exhibitor Package is priced at £500 and includes: EXHIBITION STANDS ARE NOW FULLY BOOKED

– A six foot trestle table and chairs
– Access to electricity and wi-fi
– Logo inclusion in pdf of delegate handbook, website and rolling slides
– Exhibitors promotional page in a pdf delegate handbook
– One stand personnel with access to technical sessions

We are also seeking sponsorship from organisations supporting the low registration fees offered to students. You can support and sponsor this meeting by clicking the booking link above.

We are grateful to our confirmed sponsors for their valued support.



Organizing Committee
Nicole Hamblin, Charles River (Chair)
Adrian Hall, UCB (Treasurer)
David Hirst, MSD

Secretariat Contact and Further Information
Hg3 Conferences Ltd
+44 (0)1423 529333