BMCS 4th Synthesis in Drug Discovery and Development 2024
Event
BMCS 4th Synthesis in Drug Discovery and Development
Dates
Tuesday 4th – Wednesday 5th June, 2024
Place
Virtual (Zoom)
Important links and downloads
Hashtag for X – #SDDD24
First announcement poster – click here to download
Second announcement poster – click here to download
Posters
Please click the poster number to view the poster.
P01 – Archana Shirsat, Diksha Rai, Balasaheb Ghotekar, Suvarn Kulkarni*
Synthesis of Conjugation Ready Bacterial Trisaccharide Repeating Unit of Staphylococcus aureus Strain M
archanashirsat@iitb.ac.in
P03 – Matthew Holland, Fernanda Duarte, Paul Brennan
Aromatic Heterocyclic Bioisosteres of the Future: A computational search of chemical space reveals previously unsynthesised potential bioisosteres
matthew.holland@cmd.ox.ac.uk
P04 – Haya Alsubaie, Alistair Brown, Jonathan Sellars
Design and synthesis of novel small-molecule inhibitors of proteasomal accessory factor A (PafA) for the treatment of Mycobacterium tuberculosis
H.S.N.Alsubaie2@newcastle.ac.uk
P05 – Jennyfer Goujon-Ricci, Kirsty Wilson, Nahoum Anthony, Robbie Burton, Natalie Tatum, Susan Tudhope, Mike Waring, Steve Wedge, Martin Noble, Ian Hickson, Ian Hardcastle
DGK inhibitors, hit validation of initial HTS
jennyfer.goujon-ricci@newcastle.ac.uk
P06 – Peter Dodd, Michael Thomas, Stephen Brand, Manu DeRycker, Fabio Zuccutto, Iva Lukac, Eun-Jung Ko, Sujatha Manthri, Kate McGonagle, Maria Osuna-Cabello
Scaffold-Hopping Strategy and Bespoke Syntheses Towards a Clinical Candidate For Visceral Leishmaniasis
p.g.dodd@dundee.ac.uk
Synopsis
Synthesis is at the heart of drug discovery and development. The industry has increasingly demanded higher quality clinical candidates and has sought to exploit less druggable biological targets. Densely functionalised small molecules with a high degree of synthetic complexity are often the result of these demands. Successful programmes therefore require the application of innovative synthesis in all stages of discovery and development. The medicinal chemist’s toolbox is also enhanced by the introduction of novel bioisosteres, often made available only through the application of new synthetic methods. This symposium aims to celebrate the crucial role of synthesis in the success of drug discovery and development.
Who should attend?
Chemists from industry and academia, including synthetic, medicinal, agroscience, and process chemists.
Want to become a member?
To join the RSC in order to qualify for discounted registration fees at all RSC events, please follow this RSC link.
Registration
Registration is now closed.
Call for Abstracts
Abstract submission is now closed.
Programme
Please note that this is a provisional programme and is subject to change.
Tuesday 4th June
| 13.00 | Opening remarks |
| 13.05 - 15.05 | Session 1 Chair: Martin Swarbrick, Ryvu Therapeutics |
| 13.05 | Non-classical bioisosteres for medicinal chemistry Pavel Mykhailiuk, Enamine |
| 13.45 | Target-based anti-infective drug discovery Anna Hirsch, Helmholtz Institute for Pharmaceutical Research Saarland discovery |
| 14.25 | Biocatalytic single-step reactions and cascades to bioactive motifs Helen Hailes, University College London |
| 15.05 | Refreshment break |
| 15.20 - 17.00 | Session 2 Chair: Pradip Songara, Rothamsted |
| 15.20 | Flash talks |
| 15.40 | Investigating c-h activation chemistry of n-phenyl azoles: the discovery of rimisoxafen Thomas Stevenson, FMC |
| 16.20 | Single Atom Logic for Skeletal Editing Mark Levin, University of Chicago |
| 17.00 | Close |
Wednesday 5th June
| 13.00 - 15.05 | Session 3 Chair: Andrew Williams, Hon Chairman, RSC BMCS |
| 13.05 | Evolution of scalable routes to the novel KRASG12C inhibitor AZD4625 Scott Lamont, AstraZeneca |
| 13.45 | Data-driven exploration of reaction space Mimi Hii, Imperial College London |
| 14.25 | Adventures in Process Development Katherine Wheelhouse, GSK |
| 15.05 | Refreshment break |
| 15.20 - 17.25 | Session 4 Chair: Katherine Jones, Charles River |
| 15.20 | High-Throughput Experimentation to Accelerate Medicinal Chemistry Programs Pablo Gabriel, Novartis |
| 16.00 | Discovery synthesis and enablement of Danuglipron, a small molecule GLP-1 agonist Scott Bagley, Pfizer |
| 16.40 | Your Chemistry has got Potential: Highly reactive intermediates without the “bang” Kevin Lam, University of Greenwich |
| 17.20 | Poster Award |
| 17.25 | Closing remarks |
| 17.30 | Close |
Exhibition/Sponsor Opportunities
Exhibitor package is priced at £100.00 and includes:
– Name and URL link on BMCS event page
– Company logo included in the electronic handbook and rolling slides at the event
– A4 promotional page in the electronic handbook
Note: no delegate registration is included
Exhibitor plus package is priced at £300.00 and includes:
– Name and URL link on BMCs event page
– Company logo included in the electronic handbook and rolling slides at the event
– A4 promotional page in the electronic handbook
– 3 minute pre-recorded video to be played on loop during the breaks
Note: no delegate registration is included
Exhibitors
Sponsors
Organising Committee
Katherine Jones, Charles River (Chair)
Martin Swarbrick, Ryvu Therapeutics (Treasurer)
Andrew Williams, RSC BMCS
Pradip Songara, Rothamsted Research
Secretariat Contact and Further Information
Hg3 Conferences Ltd
+44 (0)1423 529333
E-mail
