8th Fragment-based Drug Discovery Meeting

8th RSC-BMCS Fragment-based Drug Discovery Meeting

Sunday – Tuesday, 27th-29th March 2022

Churchill College, Cambridge plus Virtual

Churchill College




Churchill College

Important links
Twitter hashtag – #Fragments22
For Delegate registration, click here
For Exhibitor bookings, click here
To sponsor the meeting, click here
Bursary application form
To submit an abstract, please click here

The aim of the 8th RSC-BMCS Fragment-based Drug Discovery meeting will be to continue the focus on case studies in Fragment-based Drug Discovery that have delivered compounds to late stage medicinal chemistry, preclinical or clinical programmes. The Fragment series was started in 2007 and continues with this theme in having over three-quarters of the presentations focused on case studies. This will be complemented by technology progress in high concentration, NMR, SPR and X-ray screening.

Who should attend
This conference is suitable for scientists including chemists, biophysicists, structural biologists, etc., with either existing experience of fragments or wanting to learn about this exciting approach to drug discovery. This international meeting attracts delegates from the UK, several mainland European counties, as well as from the USA, Japan, China and South Korea.

Pre-conference workshop
A pre-conference workshop is planned with some new material to offer those new to the area of FBLD, including an introduction into the fundamental principles governing fragment-based drug discovery approaches. A series of four short presentations with opportunities for discussions is planned. The pre-conference workshop will only be held if sufficient interest is evident, and will be offered free-of-charge to conference attendees.

Call for Posters / Abstracts
Abstract submission is now open, click here to submit your abstract.
The closing date for abstract submission is Midnight (GMT), Friday 10th December.

Sunday, 27th March

Registration opens
Session chair: TBC

Refreshments and networking
Buffet supper in College

Monday, 28th March

09.15Registration and refreshments
10.20Opening remarks
10.30Session 1:
Session chair: TBC

FBLD-Enabled Discovery of cGAS Inhibitors
Katrin Groebke Zbinden and Fabio Casagrande, Roche
11.00The Discovery and optimisation of small molecule Inhibitors of TNF - Using Fragments to Inhibit a Protein: Protein Interaction
James O’Connell, UCB
11.30Session 2: Flash poster presentations
Session chair: TBC
12.00Lunch, exhibition, poster session (odd-numbers) and networking
13.30Session 3:
Session chair: TBC

Covalent Fragment Screening
Nir London, Weismann Institute
14.00Reactive fragment profiling against the DUBome by MS-proteomics
Rosa Cookson, GSK
14.30Reimagining Druggability using Chemoproteomic Platforms
Dan Nomura, University of California
15.00Refreshments, exhibition, posters (odd-numbers) and networking
15:30Session 4: Panel discussion
Session chair: TBC

Thoughts on the future for FBDD
Gianni Chessari, Astex

Fragments: Impact, Lessons and What's Next?
Roderick Hubbard, University of York and Vernalis
16:30Refreshments, exhibition, posters (odd-numbers) and networking
18.20Walk to conference dinner
19.00Reception and conference dinner at St Johns College

Tuesday, 29th March

9.30Session 5:
Session chair: TBC

SpotXplorer fragments for maximal coverage of pharmacophore space
György M Keserű, Research Centre for Natural Sciences (RCNS)
10.00Enabling CryoEM for SBDD and FBDD
Pamela Williams, Astex
10.30Refreshments, exhibition, posters (even numbers) and networking
11.00Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures
Lisa Baker, Vernalis
11.30GPCR Fragment-Based Drug Discovery
Ijen Chen, Sosei Heptares
Chris de Graaf, Sosei Heptares
12.00Lunch, exhibition, poster session (even numbers) and networking
13.30Session 6:
Session chair: TBC

Crystallographic fragment screening identifies sixty diverse inhibitors of carboxylesterase Notum. An example of hit selection, validation and optimisation to ARUK3001185.
Paul Fish, ARUK UCL Drug Discovery Institute
14.00The discovery of CFTX-1554 as an inhibitor angiotensin II type 2 receptor, a clinically validated target for the treatment of neuropathic pain
Ann de Blieck, Confo Therapeutics
14.30Refreshments, exhibition, posters (even numbers) and networking
15.00Fragment-based design of methionine adenosyl transferase (MAT2a) inhibitors with anti-tumour effect
Marianne Schimpl and Ulf Borjesson, AstraZeneca
15.30From Fragments to PROTACs: Identification of potent, selective and orally bioavailable SMARCA2 PROTAC
Christiane Kofnik, Boehringer Ingelheim
16.00Fragment based discovery of MRTX1719, a selective inhibitor of the PRMT5.MTA complex for the treatment of MTAP deleted tumours
Christopher Smith, Mirati Therapeutics
16.30Closing remarks

Close and depart

Conference dinner
The conference dinner will take place on Monday 28th March at St Johns College.  This is a semi-formal evening and is a great time to come together to enjoy a three-course meal.

St Johns College

St Johns College Dining Room

Registration is now open, click here to register
In person registration deadline: Monday 21st March 17:00 (GMT)
Online attendance registration will remain open throughout the duration of the meeting

Registration Fees
Earlybird rate available until 24th January, 2022
RSC Member* £300
Non-member £380
RSC Student** Member* £155
Student** Non-member £195

Standard rate available from 25th January, 2022
RSC Member* £360
Non-member £450
RSC Student** Member* £185
Student** Non-member £230

Online only rate
RSC Member* £200
Non-member £250
RSC Student** Member* £100
Student** Non-member £120

* Member is a paid-up member of the RSC
** Student rates apply to undergraduate and post-graduate students only, but not post-doctoral students.

Want to become a member?
To join the RSC in order to qualify for discounted registration fees at all RSC, please follow this RSC link.

Student Bursaries
The RSC BMCS are offering some student bursaries to attend this meeting in person. Applications are open to PhD and post-doctoral applicants studying at academic institutions. Preference will be given to members of the RSC, a National Adhering Organisation of the EFMC, and any co-sponsoring organisation. Further information can be found here.
The closing date for applications is 31st January.  Please download the bursary application form here.

Exhibitor/Sponsorship Opportunities
Bookings are now open, click here to book an exhibitor stand, or sponsor the meeting

The Exhibitor Package is priced at £750 and includes:
– A six foot trestle table and chair(s);
– A blue baize table cloth;
– Access to electricity and Wi-fi;
– Logo inclusion in delegate handbook and rolling slides;
– Exhibitors promotional page in the printed delegate handbook.

£146 Exhibitor stand personal rate (no access to the technical sessions, conference dinner excluded);
£72 Conference dinner for exhibitor personnel;
£275 Delegate pack inserts

We are also seeking sponsorship from organisations supporting the low registration fees offered to students.  You can support and sponsor this meeting by clicking the booking link above.


Our Exhibitors/Sponsors
We are grateful to our confirmed exhibitors/sponsors for their valued support.





Organising Committee
Mike Hann, GSK
Samantha Hughes, AstraZeneca
Darryl McConnell, Boehringer Ingelheim
Gordon Saxty, Fidelta d.o.o. (Chair)
Mary Wheldon, University of Dundee (Treasurer)
Alison Woolford, Astex Pharmaceuticals

Secretariat Contact
Hg3 Conferences Ltd
+44 (0)1423 529333